Differential metabolism of drugs, therapeutic effects and side effects.

I’m going to look into this with my doc and see if we have this test available in South Africa. Obviously affordability will be a factor, but after my failed attempts with olanzapine and quetiapine due to adverse side effects, I’d be interested to know. It would be nice to not have to go through the whole ordeal of ‘trying’ a drug out and getting sick, before trying an alternative.



We all have an enzyme system in our liver called the Cytochrome P-450 (CP-450) system. It evolved to metabolize poisons, but it is the major enzyme system that metabolizes drugs. This means it breaks drugs down into their metabolites, (or adds sulfate, acetyl, methyl, glucuronidyl gorups) which makes them more water soluble, and gets rid of them.

There are many forms of CP-450, ones that are fast, medium, slow, or super slow. The fast CP-450 breaks down the drug you’ve taken quickly. This hopefully allows enough time for the drug to interact with the proper receptors and have its desired effect before it is removed from your circulation. The slow and super slow CP-450 can be problematic in that they remove the drug so slowly that side effects and worse, adverse effects take place.

I have had genetic testing done to see which form of CP-450 I have. I have the…

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